منابع مشابه
Epigenetic regulation in drug addiction.
The interaction between environmental signals and genes has now taken on a clear molecular form as demonstrated by stable changes in chromatin structure. These changes occur through activation or repression of specific gene programmes by a combination of chromatin remodelling, activation and enzymatic modification of DNA and histones as well as nucleosomal subunit exchange. Recent research inve...
متن کاملMechanisms of epigenetic memory and addiction.
Epigenetic regulation of cellular identity and function is at least partly achieved through changes in covalent modifications on DNA and histones. Much progress has been made in recent years to understand how these covalent modifications affect cell identity and function. Despite the advances, whether and how epigenetic factors contribute to memory formation is still poorly understood. In this ...
متن کاملTranscriptional Mechanisms of Drug Addiction
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to regulatory regions of specific genes and thereby control levels of their expression, have been implicated in the addiction process over the past decade or two. Here we review the g...
متن کاملMolecular mechanisms of drug addiction.
Regulation of gene expression is one mechanism by which drugs of abuse can induce relatively long-lasting changes in the brain to cause a state of addiction. Here, we focus on two transcription factors, CREB (cAMP response element binding protein) and DeltaFosB, which contribute to drug-induced changes in gene expression. Both are activated in the nucleus accumbens, a major brain reward region,...
متن کامل[Molecular and neuronal mechanisms of drug addiction].
Drug addiction is believed to be a chronic and convertible disease resulting in the obtrusive aim of drugs ingestion and the use of them in spite of health risk and life threat. Human behavior is mainly a resultant force of 3 actions of the functional CNS: arousal, reward and cognition. In addition all of them are advanced in the development of drug addiction. For the proper functioning of ever...
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ژورنال
عنوان ژورنال: Neuropharmacology
سال: 2014
ISSN: 0028-3908
DOI: 10.1016/j.neuropharm.2013.04.004